It is IRF's overall assessment that racecadotril may be a relevant symptomatic treatment option in acute diarrhoea in adults. Compared to placebo, racecadotril reduces the duration of diarrhoea by approx. 24 hours. This effect is equivalent with loperamide. However, racecadotril causes fewer adverse reactions than loperamide and does not reduce peristalsis. The treatment price of racecadotril, although higher than that of loperamide, is acceptable in light of the fewer adverse reactions.
Treatment with racecadotril does not replace rehydration therapy when relevant.